Micronutrient deficiencies in patients with COVID-19: how metabolomics can contribute to their prevention and replenishment.
Dimitris Tsoukalas1,2 and Evangelia Sarandi2,3

BMJ Nutrition, Prevention & Health. Nov. 2020; bmjnph-2020-000169
Author affiliations
1. European Institute of Nutritional Medicine, Rome, Italy
2. Metabolomic Medicine, Athens, Greece
3. Laboratory of Toxicology and Forensic Sciences, Medical School of the University of Crete, Crete, GreeceView Full
Text: http://dx.doi.org/10.1136/bmjnph-2020-000169

A Clinical Trial for the Identification of Metabolic Biomarkers in Hashimoto’s Thyroiditis and in Psoriasis: Study Protocol
Evangelia Sarandi, Sabine Kruger Krasagakis, Dimitris Tsoukalas, Gottfried Rudofsky, Aristides Tsatsakis

ISP Pathophysiology  https://doi.org/10.3390/pathophysiology28020019 

The snapshot of metabolic health in evaluating micronutrient status, the risk of infection and clinical outcome of COVID-19
Dimitris Tsoukalas 1 Evangelia Sarandi 1 Spyridoula Georgaki 1 Show footnotes Open AccessPublished:June 26, 2021

Clinical Nutrition ESPEN
DOI: https://doi.org/10.1016/j.clnesp.2021.06.011

Prediction of Autoimmune Diseases by Targeted Metabolomic Assay of Urinary Organic Acids.
Dimitris Tsoukalas 1 2 3, Vassileios Fragoulakis 4, Evangelos Papakonstantinou 2, Maria Antonaki 5, Athanassios Vozikis 5, Aristidis Tsatsakis 6 7, Ana Maria Buga 8, Mihaela Mitroi 9, Daniela Calina 1

Metabolites. 2020 Dec 8. 

Affiliations
– Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
– Metabolomic Medicine, Health Clinic for Autoimmune and Chronic Diseases, 10674 Athens, Greece.
– European Institute of Nutritional Medicine (E.I.Nu.M.), 00198 Rome, Italy.
– The Golden Helix Foundation, London WC2N 5AP, UK.
– Laboratory of Health Economics & Management, Economics Department, University of Piraeus, 18534 Piraeus, Greece.
– Laboratory of Toxicology and Forensic Sciences, Medical School, University of Crete, 71003 Heraklion, Greece.
– Department of Analytical and Forensic Medical Toxicology, Sechenov University, 119991 Moscow, Russia.
– Department of Biochemistry, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
– ENT Department, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
DOI: 10.3390/metabo10120502

Non-communicable Diseases in the Era of Precision Medicine: An Overview of the Causing Factors and Prospects.
Dimitris Tsoukalas12, Evangelia Sarandi12, Maria Thanasoula1.
In: Koukios E., Sacio-Szymańska A. (eds) 

1. European Institute of Nutritional Medicine, E.I.Nu.MRomeItaly

2. Metabolomic Medicine ClinicAthensGreece

3. Laboratory of Toxicology and Forensic Sciences, Medical SchoolUniversity of CreteHeraklionGreece

   Bio#Futures. Springer, Cham. May 2021.

Sufficient vitamin D status positively modified ventilatory function in asthmatic children following a Mediterranean diet enriched with fatty fish intervention study
M.Papamichaela, CatherineItsiopoulosae, KatrinaLambertb,CharisKatsardisc, DimitrisTsoukalasd, BircanErbasb,
– La Trobe University, School of Allied Health, Human Services &Sport, Department of Dietetics, Nutrition & Sport, Melbourne, Australia
– La Trobe University, School of Psychology & Public Health, Department of Public Health, Melbourne, Australia
– National & Kapodistrian University of Athens, Athens, Greece
-d European Institute of Nutritional Medicine, Rome, Italy
– Murdoch University, College of Science, Health, Engineering & Education, Perth, Australia
Nutrition Research, 16 August 2020
https://doi.org/10.1016/j.nutres.2020.08.004 

Metabolic profiling of organic and fatty acids in chronic and autoimmune diseases
EvangeliaSarandiab MariaThanasoulaac ChrisanthiAnamateroua EvangelosPapakonstantinoua FrancoGeracic Maria MichellePapamichaeld CatherineItsiopoulosd DimitrisTsoukalasac
– Metabolomic Medicine Clinic, Athens, Greece
– Laboratory of Toxicology and Forensic Sciences, Medical School, University of Crete, Heraklion, Greece
– European Institute of Nutritional Medicine, E.I.Nu.M, Rome, Italy
– Department of Rehabilitation, Nutrition & Sport, La Trobe University, School of Allied Health, Melbourne, VIC, Australia
Advances in Clinical Chemistry, 15 July 2020. 
https://doi.org/10.1016/bs.acc.2020.06.003

Potential role of folate status on pulmonary function in pediatric asthma 
Maria Michelle Papamichael Ph.D.ab, CharisKatsardis M.D., Ph.D.c Dimitris Tsoukalas M.D.b Katrina Lambert Ph.D.d Bircan Erbas Ph.D.df Catherine Itsiopoulos Ph.D.ae.
– La Trobe University, School of Allied Health, Department of Dietetics, Nutrition & Sport, Melbourne, Australia
– European Institute of Nutritional Medicine, Rome, Italy
– National & Kapodistrian University of Athens, Athens, Greece
– La Trobe University, School of Psychology & Public Health, Department of Public Health, Melbourne, Australia e RMIT University, School of Health and Biomedical Sciences, Melbourne, Australia
– Universitas Airlangga, Faculty of Public Health, Surabaya, Indonesia
Nutrition, Elsevier. Volume 90, Oct. 2021  
https://doi.org/10.1016/j.nut.2021.111267 

Analysis of the Intricate Effects of Polyunsaturated Fatty Acids and Polyphenols on Inflammatory Pathways in Health and Disease.
Denisa Margină, Anca Ungurianu, Carmen Purdel, George Mihai Nitulescu, Dimitris Tsoukalas, Evangelia Sarandi, Maria Thanasoula, Tatyana I Burykina, Fotis Tekos, Aleksandra Buha, Dragana Nikitovic, Demetrios Kouretas, Aristidis Michael Tsatsakis.

Food Chem Toxicol . 2020 Jul.  
PubMed https://pubmed.ncbi.nlm.nih.gov/32640331/
DOI: 10.1016/j.fct.2020.111558.

Chronic Inflammation in the Context of Everyday Life: Dietary Changes as Mitigating Factors.
Margină, D.; Ungurianu, A.; Purdel, C.; Tsoukalas, D.; Sarandi, E.; Thanasoula, M.; Tekos, F.; Mesnage, R.;  Kouretas, D.; Tsatsakis, A.

Int. J. Environ. Res. Public Health 2020, 17, 4135.
PMC7312944   
PMID: 32531935
DOI: 10.3390/ijerph17114135

Telomerase and telomeres in aging theory and chronographic aging theory (Review)
Mayya P Razgonova 1, Alexander M Zakharenko 1, Kirill S Golokhvast 1, Maria Thanasoula 2, Evangelia Sarandi 2, Konstantinos Nikolouzakis 3, Persefoni Fragkiadaki 3, Dimitris Tsoukalas 2, Demetrios A Spandidos 4, Aristidis Tsatsakis 3

Affiliations

N.I. Vavilov All‑Russian Institute of Plant Genetic Resources, 190000 Saint‑Petersburg, Russia.

Metabolomic Μedicine, Health Clinics for Autoimmune and Chronic Diseases, 10674 Athens, Greece.

Laboratory of Toxicology, Medical School, University of Crete, 71003 Heraklion, Greece.

Laboratory of Clinical Virology, School of Medicine, University of Crete, Heraklion 71003, Greece.

PMID: 32705188
DOI: 10.3892/mmr.2020.11274

Metabolic Fingerprint of Chronic Obstructive Lung Diseases: A New Diagnostic Perspective  
Dimitris Tsoukalas, Evangelia Sarandi , Maria Thanasoula, Anca Oana Docea, Gerasimos Tsilimidos, Daniela Calina, and Aristides Tsatsakis

Metabolites 2019, 9(12), 290; Published: 26 November 2019
https://doi.org/10.3390/metabo9120290  

Targeted Metabolomic Analysis of Serum Fatty Acids for the Prediction of Autoimmune Diseases 
Dimitris Tsoukalas, Vassileios Fragoulakis, Evangelia Sarandi, Anca Oana Docea, Evangelos Papakonstaninou, Gerasimos Tsilimidos, Chrysanthi Anamaterou, Persefoni Fragkiadaki, Michael Aschner, Aristidis Tsatsakis, Nikolaos Drakoulis, Daniela Calina
Frontiers in Molecular Biosciences, Metabolomics (6), 2019, Published 1 November 2019  
DOI: 10.3389/fmolb.2019.00120   

COVID‑19 in Northern Italy: An integrative overview of factors possibly influencing the sharp increase of the outbreak (Review).
Marina Goumenou 1, Dimosthenis Sarigiannis 2, Aristidis Tsatsakis 1, Ourania Anesti 1, Anca Oana Docea 3, Dimitrios Petrakis 1, Dimitris Tsoukalas 4, Ronald Kostoff 5, Valeri Rakitskii 6, Demetrios A Spandidos 7, Michael Aschner 8, Daniela Calina 9 

Affiliations

1. Center of Toxicology Science and Research, Medical School, University of Crete, 71003 Heraklion, Greece.

2. HERACLES Research Center on the Exposome and Health, Center for Interdisciplinary Research and Innovation, Aristotle University of Thessaloniki, 57001 Thessaloniki, Greece.

3. Department of Toxicology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.

4. Metabolomic Medicine, Health Clinics for Autoimmune and Chronic Diseases, 10674 Athens, Greece.

5. Research Affiliate, School of Public Policy, Georgia Institute of Technology, Gainesville, VA 20155, USA.

6. Federal Scientific Center of Hygiene, F.F. Erisman, 141014 Moscow, Russia.

7. Laboratory of Clinical Virology, Medical School, University of Crete, 71003 Heraklion, Greece.

8. I.M. Sechenov First Moscow State Medical University (Sechenov University), 119146 Moscow, Russia.

9. Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.    

Molecular Medicine Reports. April 16, 2020.  
DOI: 10.3892/mmr.2020.11079

A New Threat From an Old Enemy: Re‑emergence of Coronavirus (Review). Int J Mol Med . 2020 Jun
Anca Oana Docea 1, Aristidis Tsatsakis 2, Dana Albulescu 3, Oana Cristea 4, Ovidiu Zlatian 4, Marco Vinceti 5, Sterghios A Moschos 6, Dimitris Tsoukalas 7, Marina Goumenou 2, Nikolaos Drakoulis 8, Josef M Dumanov 9, Victor A Tutelyan 10, Gennadii G Onischenko 10, Michael Aschner 11, Demetrios A Spandidos 12, Daniela Calina 13
Affiliations

Department of Toxicology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.

Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, 71003 Heraklion, Greece.

Department of Radiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.

Department of Microbiology, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.

Department of Biomedical, Metabolic and Neural Sciences, University of Modena and Reggio Emilia, I‑41125 Modena, Italy.

Department of Applied Sciences, Faculty of Health and Life Sciences, Northumbria University, Newcastle‑Upon‑Tyne NE1 8ST, UK.

Metabolomic Medicine, Health Clinics for Autoimmune and Chronic Diseases, 10674 Athens, Greece.

Research Group of Clinical Pharmacology and Pharmacogenomics, Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, 15771 Athens, Greece.

Mycological Institute US EU, Subclinical Research Group, Sparta, NJ 07871, USA.

Russian Academy of Sciences, 119991 Moscow, Russia.

The State Education Institution of Higher Professional Training, The First Sechenov Moscow State Medical University under Ministry of Health of the Russian Federation, 119992 Moscow, Russia.

Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece.

Department of Clinical Pharmacy, University of Medicine and Pharmacy of Craiova, 200349 Craiova, Romania.
DOI:10.3892/ijmm.2020.4555  

Acknowledgement to Reviewers of High-Throughput in 2019
by High-Throughput Editorial Office MDPI, Basel, Switzerland.   
Jan 2020, https://doi.org/10.3390/ht9010002    

Sperm telomere length: Diagnostic and prognostic biomarker in male infertility (Review)
Saira Amir, Elena Vakonaki, Konstantina Tsiminikaki, Manolis N. Tzatzarakis, Vasiliki Michopoulou, Matthaios Flamourakis, Katerina Kalliantasi, Vasiliki Karzi, Persefoni Fragkiadaki, Elisavet A. Renieri, Dimitris Tsoukalas, Maria Thanasoula, Evangelia Sarandi, George Sakellaris, Antonios Makrigiannakis, Charitini Nepka, Demetrios A. Spandidos, Aristidis Tsatsakis.  

World Academy of Sciences Journal 2020-01-02 | journal-article DOI: 10.3892/wasj.2020.31

A Review of the Alleged Health Hazards of Monosodium Glutamate   
Οne of the top downloaded studies in recent publication history, 2018-2019.  
Anca Zanfirescu 1, Anca Ungurianu 1, Aristides M Tsatsakis 2, George M Nițulescu 1, Demetrios Kouretas 3, Aris Veskoukis 3, Dimitrios Tsoukalas 2 4, Ayse B Engin 5, Michael Aschner 6, Denisa Margină 1   

Affiliations
1 Faculty of Pharmacy, “Carol Davila” University of Medicine and Pharmacy, Traian Vuia 6, Bucharest 020956, Romania.
2 Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, Heraklion 71409, Crete, Greece.
3 Department of Biochemistry and Biotechnology, University of Thessaly, Larissa 41500, Greece.
4 Metabolomic Medicine Clinic, Athens 10674, Greece.
5 Gazi University, Faculty of Pharmacy, Department of Toxicology, Ankara 06330, Turkey.
6 Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx NY 10463, USA.
PMID: 31920467 PMCID: PMC6952072 DOI: 10.1111/1541-4337.12448
Comprehensive Reviews in Food Science and Food Safety.  
First published: 08 May 2019  
https://doi.org/10.1111/1541-4337.12448

Weight Status and Respiratory Health in Asthmatic Children.  
Maria Michelle Papamichael, Charis Katsardis, Dimitris Tsoukalas, Bircan Erbas, Catherine Itsiopoulos   

Lung Springer Nature Published online 14 September 2019 (p1-6)
Doi: 10.1007/s00408-019-00273-w.   

The importance of vitamin D status on lung function in asthmatic children   
Maria M Papamichael, Katrina Lambert, Dimitris Tsoukalas, Michael Koutsilieris, Charis Katsardis, Bircan Erbas and Catherine Itsiopoulos
J Clin Nutr Diet, DOI: 10.4172/2472-1921-C1-005 presented at 3rd World Congress on Nutrition, Dietetics and Nutraceuticals in Prague, 2019 (p.38)  

Clinical aspects of precision medicine using as biomarkers telomere length, fatty acids and organic acids D Tsoukalas   
TOXICOLOGY LETTERS 314, S29-S29

Discovery of potent telomerase activators: Unfolding new therapeutic and anti-aging perspectives    
Dimitris Tsoukalas, Persefoni Fragkiadaki, Anca Oana Docea, Athanasios K. Alegakis, Evangelia Sarandi, Maria Thanasoula, Demetrios A. Spandidos, Aristidis Tsatsakis, Mayya Petrovna Razgonova, Daniela Calina
Molecular Medicine Reports Published online on: August 23, 2019  
https://doi.org/10.3892/mmr.2019.10614   

Anthropogenic Pressure and Lifestyle are the Underlying Cause of Pandemic Chronic Diseases
Dimitris Tsoukalas, Evangelia Sarandi, Aristides Tsatsakis, Daniela Calina  
Journal of Siberian Federal University. Biology 2019-09  
DOI: 10.17516/1997-1389-0297   

Metabolomica: Uno strumento della Medicina Personalizzata per le Malattie Autoimmuni e Croniche. Corso di approfondimento sulla medicina preventiva, rigenerativa e antiaging.  
Dimitris Tsoukalas , European Institute of Nutritional Medicine.
AMIA Associazione Medici Italiani Antiaging – ESAAM European Society of Anti-Aging Medicine.
*Italian Ministry of Health Accredited Continued Medical Education (AKESIOS).

Precision Medicine Advances in Childhood Atopic Diseases: Results from Atopic Dermatitis and Asthma
Dimitris Tsoukalas, Gerasimos Tsilimidos, Maria Michelle Papamichael, Charis Katsardis,Bircan Erbas, Catherine Itsiopoulos   
5th World Summit on Pediatrics Berlin, Germany, 20/06/2019 – 23/06/2019 
*Accredited by the the European Accreditation Council for Continuing Medical Education (EACCME®)   

Association of nutraceutical supplements with longer telomere length  
Dimitris Tsoukalas, Persefoni Fragkiadaki, Anca Oana Docea, Athanasios K. Alegakis, Evangelia Sarandi, Elena Vakonaki, Eralda Salataj, Elisavet Kouvidi, Dragana Nikitovic, Leda Kovatsi, Demetrios A. Spandidos, Aristidis Tsatsakis, Daniela Calina.
International Journal of Molecular Medicine.  
Published online on: May 10, 2019
https://doi.org/10.3892/ijmm.2019.4191
Copyright: © Tsoukalas et al.    

The association of female and male infertility with telomere length (Review)   
Eleni Vasilopoulos,Persefoni Fragkiadaki, Charikleia Kalliora, Domniki Fragou, Anca Oana Docea, Elena Vakonaki, Dimitris Tsoukalas, Daniela Calina, Ana Maria Buga, George Georgiadis, Charalampos Mamoulakis, Antonios Makrigiannakis, Demetrios A. Spandidos, and Aristidis
Tsatsakis.Int J Mol Med. 2019 Aug; 44(2): 375–389.    

Developing BIOTEL: A Semi-Automated Spreadsheet for Estimating Telomere Length and Biological Age.
Tsatsakis Aristidis, Tsoukalas Dimitrios, Fragkiadaki Persefoni, Vakonaki Elena, Tzatzarakis Manolis, Sarandi Evangelia, Nikitovic Dragana, Tsilimidos Gerasimos, Alegakis Athanasio.  
Frontiers in Genetics 2019-02-19 | journal-article DOI: https://doi.org/10.3389/fgene.2019.00084   

A Polyphenol-Enriched Supplement Exerts Potent Epigenetic-Protective Activity in a Cell-Based Model of Brain Ischemia.  
Lara Faggi 1,†, Vanessa Porrini 1,†, Annamaria Lanzillotta 1, Marina Benarese 1, Mariana Mota 1, Dimitris Tsoukalas 2, Edoardo Parrella 1, and Marina Pizzi 1.
1. Department of Molecular and Translational Medicine, University of Brescia, Viale Europa 11, 25123 Brescia, Italy
2. European Institute of Nutritional Medicine, E.I.Nu.M., Viale Liegi 44, 00198 Rome, Italy  
Nutrients 2019, 11(2), 345; https://doi.org/10.3390/nu11020345  

Gut microbiome metagenomics to understand how xenobiotics impact human health.  
Robin Mesnage and Michael N. Antoniou and Dimitrios Tsoukalas and George N. Goulielmos and Aristides M. Tsatsakis.
Current Opinion in Toxicology 2019-02 | journal-article DOI: 10.1016/j.cotox.2019.02.002   

Effect of chronic and heavy drug abuse on biological aging.
Vakonaki, E., Tzatzarakis, M., Tsiminikaki, K., Nathena, D., Fragkiadaki, P., Kalliantasi, K., Kanaki, K., Vaki, G., Plaitis, S., Tsoukalas, D., Alegakis, A., Spandidos, D. A., Tsatsakis, A.  
World Academy of Sciences Journal 2019-02-05 | journal-article
DOI: 10.3892/wasj.2019.7   

Application of metabolomics part II: Focus on fatty acids and their metabolites in healthy adults   
Authors: Dimitrios Tsoukalas, Athanasios K. Alegakis, Persefoni Fragkiadaki, Evangelos Papakonstantinou, Gerasimos Tsilimidos, Franco Geraci, Evangelia Sarandi, Dragana Nikitovic, Demetrios A. Spandidos, Aristides Tsatsakis.
Affiliations: Laboratory of Toxicology and Forensic Sciences, Medical School, University of Crete, 71003 Heraklion, Greece, Metabolomic Medicine Clinic, 10674 Athens, Greece, European Institute of Nutritional Medicine, E.I.Nu.M, 00198 Rome, Italy, Laboratory of Anatomy‑Histology-Embryology, School of Medicine, University of Crete, 71003 Heraklion, Greece, Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece  
International Journal of Molecular Medicine. Published online on: November 14, 2018 https://doi.org/10.3892/ijmm.2018.3989
Copyright: © Tsoukalas et al. This is an open-access article distributed under the terms of Creative Commons Attribution License.

Efficacy of a Mediterranean diet supplemented with fatty fish in ameliorating inflammation in paediatric asthma: a randomised controlled trial.   
M. M. Papamichael,1 Ch. Katsardis,2 K. Lambert,3 D. Tsoukalas,4 M. Koutsilieris,2 B. Erbas3 & C. Itsiopoulos1
1. Department of Rehabilitation, Nutrition & Sport, School of Allied Health, La Trobe University, Melbourne, VIC, Australia.
2. National & Kapodistrian University of Athens, Athens, Greece
3. Department of Public Health, School of Psychology & Public Health, La Trobe University, Melbourne, VIC, Australia
4. European Institute of Nutritional Medicine, Rome, Italy   

J Hum Nutr Diet. 2018 Oct 30. doi: 10.1111/jhn.12609. The official journal of the British Dietetic Association.

The Akt pathway in oncology therapy and beyond (Review).  
Nitulescu GM, Van De Venter M, Nitulescu G, Ungurianu A, Juzenas P, Peng Q, Olaru OT, Grădinaru D, Tsatsakis A, Tsoukalas D, Spandidos DA, Margina D.
1. Faculty of Pharmacy, ‘Carol Davila’ University of Medicine and Pharmacy, 020956 Bucharest, Romania.
2. Department of Biochemistry and Microbiology, Nelson Mandela University, Port Elizabeth 6031, South Africa.
3. Department of Pathology, Radiumhospitalet, Oslo University Hospital, 0379 Oslo, Norway.
4. Department of Forensic Sciences and Toxicology, Faculty of Medicine, University of Crete, 71003 Heraklion, Greece.
5. Laboratory of Clinical Virology, School of Medicine, University of Crete, 71003 Heraklion, Greece.  
Int J Oncol. 2018 Oct 16. doi: 10.3892/ijo.2018.4597

Decreased telomeres length in patients with glioblastoma multiform  
E.K.Vakonaki, G.A.Vaki, K.Tsiminikaki, A.Alegkakis K.Kalliantasi, P. Fragkiadaki, M.Flamourakis, D. Tsoukalas, I. Fragkiadoulaki, M.N.Tzatzarakis, A.M.Tsatsakis
Medical School, University of Crete, Laboratory of Toxicology, Heraklion, Crete, Greece   
Toxicology Letters Volume 295, Supplement 1, 10 October 2018, Page S92
https://doi.org/10.1016/j.toxlet.2018.06.582

Urinary organic acids as biomarkers in the assessment of pulmonary function in children with asthma   
Maria Michelle Papamichaela, Chris Katsardisc, Bircan Erbasb, Catherine Itsiopoulosa, Dimitris Tsoukalasd
a La Trobe University, School of Allied Health, Department of Rehabilitation, Nutrition & Sport, Melbourne, Australia
b La Trobe University, School of Psychology & Public Health, Department of Public Health, Melbourne, Australia
c National & Kapodistrian University of Athens, Athens, Greece
d European Institute of Nutritional Medicine, Rome, Italy  
Nutrition Research, Elsevier. October 2018.
https://doi.org/10.1016/j.nutres.2018.10.004

World aging population, chronic diseases and impact of modifiable-metabolic risk factors

Dr. Dimitris Tsoukalas, MD (Greece). European Institute of Nutritional Medicine, E.I.Nu.M.  
20th International Congress of Rural Medicine 2018. Tokyo – Japan

Tsoukalas D. Physician. European Institute of Nutritional Medicine, E.I.Nu.M.
Healthy Ageing an endless challenge. 35th Balkan Medical Week Congress, 25-17 Sept. 2018 Athens Greece

The effect of supplements on telomere length   
Fragkiadaki P1,2, Tsoukalas D1,3, Alegkakis A1, Sarandi E1,3, Tsatsakis A1,2
1.Center of Toxicology Science and Research, University of Crete, Heraklion, Crete, Greece
2. Toxplus spin off S.A., Heraklion 71601
3. Metabolomic Medicine Clinic, Athens 10674    
Healthy Ageing an endless challenge. 35th Balkan Medical Week Congress, 25-17 Sept. 2018 Athens Greece   

Modulation of the Process of Aging in Human Organism: Recent Advances in Biomarkers for Diagnosis and Treatment
Tsoukalas, Dimitrios; Fragkiadaki, Persefoni; Sarandi, Evangelia; Tsatsakis, Aristidis.  
2018 11(2): 146-156; 
Journal of Siberian Federal University SibFU Journals Biology

Stanozolol administration combined with exercise leads to decreased telomerase activity possibly associated with liver aging.   
Authors: Eren Ozcagli Mehtap Kara Tugba Kotil Persefoni Fragkiadaki Manolis N. Tzatzarakis Christina Tsitsimpikou Polychronis D. Stivaktakis Dimitrios Tsoukalas Demetrios A. Spandidos Aristides M. Tsatsakis Buket Alpertunga.
April 2018. International Journal of Molecular Medicine.
DOI10.3892/ijmm.2018.3644

Fatty fish (Ω3) – A diet therapy for paediatric asthma?  
Papamichael Maria Michelle, Κatsardis Charis, Koutsilieris Michael, Tsoukalas Dimitris, Lambert Katrina, Erbas Bircan, Itsiopoulos Catherine.
World Congress on Nutrition and Dietetics, June 18-19, Paris, France.
J Clin Nutr Diet 2018 Volume: 4. DOI: 10.4172/2472-1921-C1-002.

The prophylactic potential of fatty fish consumption on airway inflammation in childhood asthma.
Papamichael Maria Michelle, Κatsardis Charis, Koutsilieris Michael, Tsoukalas Dimitris, Lambert Katrina, Erbas Bircan, Itsiopoulos Catherine.  
17th American Pediatrics Healthcare & Infectious Diseases Congress June 27-28 2018, Vancouver, Canada.   

Omega 3 fatty acids – A new therapeutic target for childhood asthma?
Papamichael Maria Michelle, Κatsardis Charis, Koutsilieris Michael, Tsoukalas Dimitris, Lambert Katrina, Erbas Bircan, Itsiopoulos Catherine.  
14th International Congress on Advances in Natural Medicines, Nutraceuticals & Neurocognition, July 19-20, 2018 London, UK.   

Application of metabolomics: Focus on the quantification of organic acids in healthy adults.  
Tsoukalas D 1-2, Alegakis A1, Fragkiadaki P1, Papakonstantinou E2, Nikitovic D3, Karataraki A2, Nosyrev AE4, Papadakis EG5, Spandidos DA6, Drakoulis N7, Tsatsakis AM1.
1. Laboratory of Forensic Sciences and Toxicology, Medical School, University of Crete, Heraklion 71003, Greece.
2. Metabolomic Medicine Clinic, Athens 10674, Greece.
3. Laboratory of Anatomy‑Histology‑Embryology, School of Medicine, University of Crete, Heraklion 71003, Greece.
4. I.M. Sechenov First Moscow State Medical University, Moscow 119048, Russia.
5. Onassis Cardiac Surgery Centre, Athens 17674, Greece.
6. Laboratory of Clinical Virology, School of Medicine, University of Crete, Heraklion 71003, Greece.
7. Research Group of Clinical Pharmacology and Pharmacogenomics, Faculty of Pharmacy, School of Health Sciences, National and Kapodistrian University of Athens, Athens 15772, Greece.  
Int J Mol Med. 2017 May 10. doi: 10.3892/ijmm.2017.2983.   

A clinical trial on the efficacy of a Mediterranean diet enriched with fatty fish in the management of paediatric asthma: Preliminary results.  
Papamichael M, Katsardis C, Tsoukalas D, Erbas B, Itsiopoulos C. Clin Nutr ESPEN. 2018 Apr;24:184. doi: 10.1016/j.clnesp.2018.01.047. Epub 2018 Mar 22  
1. La Trobe University, School of Allied Health, Australia.
2. National & Kapodistrian University of Athens, Athens, Greece.
3. European Institute of Nutritional Medicine, Rome.
4. La Trobe University, School of Public Health, Australia.

Common mental disorders and association with telomere length (Review).   
Authors: E. Vakonaki, K. Tsiminikaki, S. Plaitis, P. Fragkiadaki, D. Tsoukalas, I. Katsikantami, G. Vaki, M. N. Tzatzarakis, D. A. Spandidos, A. M. Tsatsakis.
Affiliations: Laboratory of Toxicology Science and Research, Medical School, University of Crete, 71003 Heraklion, Crete, Greece, Laboratory of Clinical Virology, Medical School, University of Crete, 71409 Heraklion, Crete, Greece.
Biomedical Reports 2018-01-08 | journal-article DOI: 10.3892/br.2018.1040 Part of ISSN: 2049-9434

Tsatsakis b, Dimitris Tsoukalas c, Atilla Engin d
a. Gazi University, Faculty of Pharmacy, Department of Toxicology, Hipodrom, Ankara, Turkey
b. Laboratory of Toxicology and Forensics, Medical School, University of Crete, Heraklion, Crete, Greece
c. Laboratory of Toxicology, Medical School, University of Crete, Voutes, Heraklion, Crete, Greece
d. Gazi University, Faculty of Medicine, Department of General Surgery, Besevler, Ankara, Turkey.
Food and Chemical Toxicology 2017-12-27. DOI: https://doi.org/10.1016/j.fct.2017.12.055
Description
Highlights

Obesity is recognized as chronic, low-grade inflammation and increased oxidative stress.

Insulin resistance may occur due to chronic overfeeding and subsequent obesity.

Dietary polyphenols may correct obesity-related insulin resistance, dose dependently.

Dietary polyphenols decrease lipogenesis, increase lipolysis with the simultaneous stimulation of fatty acid oxidation.

Polyphenol intake can prevent high-fat diet-induced insulin resistance via cell surface G protein-coupled estrogen receptor.

Current evidence on the effect of dietary polyphenols intake on chronic diseases.
Chiara Costa and Aristidis Tsatsakis and Charalampos Mamoulakis and Michele Teodoro and Giusi Briguglio and Emanuela Caruso and Dimitris Tsoukalas and Denisa Margina and Efthimios Dardiotis and Demetrios Kouretas and Concettina Fenga.
Food and Chemical Toxicology, Volume 110, December 2017, Pages 286-299.
https://doi.org/10.1016%2Fj.fct.2017.10.023

Age-dependent endocrine disorders involved in the pathogenesis of refractory acne in women.
Ianoşi S1, Ianoşi G2, Neagoe D3, Ionescu O4, Zlatian O5, Docea AO6, Badiu C7, Sifaki M8, Tsoukalas D8, Tsatsakis AM8, Spandidos DA9, Călina D4.
Molecular Medicine Reports [04 Nov 2016, 14(6):5501-5506].
Doi: 10.3892/mmr.2016.5924. Epub 2016 Nov 4.

Telomerase activity in pregnancy complications (Review).
Fragkiadaki P1, Tsoukalas D1, Fragkiadoulaki I, Psycharakis C, Nikitovic D, Spandidos DA, Tsatsakis AM.Mol Med Rep. 2016 Jul;14(1):16-21.
Doi: 10.3892/mmr.2016.5231. Epub 2016 May 9.

HPV strain distribution in patients with genital warts in a female population sample.
Boda D1, Neagu M2, Constantin C3, Voinescu RN4, Caruntu C5, Zurac S6, Spandidos DA7, Drakoulis N8, Tsoukalas D9, Tsatsakis AM9.Oncol Lett. 2016 Sep;12(3):1779-1782. Epub 2016 Jul 22.

Development of a semi-automated database for telomere length statistics.   
Athanasios Alegkakis1, Elena Vakonaki1, Persefoni Fragkiadaki1, Manolis Tzatzaraki1, Dimitrios Tsoukalas2, Aristidis Tsatsakis1.1Laboratory of Toxicology, University of Crete, Heraklion, Greece. 2Metabolomic Clinic, Athens, Greece.
Toxicology Letters. Volume 280, Supplement 1, 20 October 2017, Page S290.
https://doi.org/10.1016/j.toxlet.2017.07.670.

The effect of TA-65 on telomerase activation and on apoptosis in human fibroblast cells.
Persefoni Fragkiadaki1, Dimitrios Tsoukalas, Chara Vlata, Aristidis M. Tsatsakis.
September 2016 Toxicology Letters. 258: S196
DOI 10.1016/j.toxlet.2016.06.1717

Telomere length in opiates and cannabis abusers as a marker of early aging.
Elena Vakonaki, Presefoni Fragkiadaki, Dimitrios Tsoukalas, Athanasios Alegkakis, Georgia Vaki, Konstantina Tsiminikaki, Stavros Plaitis, Manolis Tzatzarakis, Aristidis Tsatsakis.
Department of Toxicology, Medical School, University of Crete, Heraklion, Greece.Toxicology Letters Volume 280, Supplement 1, 20 October 2017, Page S242.
https://doi.org/10.1016/j.toxlet.2017.07.670 

Development of a semi-automated worksheet for predicting biological age and telomere length statistics for the Greek population.
Tsoukalas D, Alegakis AK, Vakonaki E, Fragkiadaki P, Tsiminikaki K, Plaitis S, Flamourakis M, Theodorakis N, Tzatzarakis M, Tsatsakis AM.conference-abstract. International conference «Hygiene, toxicology, professional pathology: traditions and modernity», dedicated to 125 anniversary of the Federal Scientific Centre of Hygiene named after F.F.Erisman. November 9-10, 2016, Moscow.

The effect of supplements on telomerase activation in human PBMC cells.
Toxicology Letters. ersefoni Fragkiadaki and Dimitrios Tsoukalas and Athanasios Alegakis and Chara Vlata and Christos Psycharakis and Aristeides Tsatsakis.Toxicology LettersVolume 280, Supplement 1, 20 October 2017, Page S319.
https://doi.org/10.1016/j.toxlet.2017.08.063

The luck of telomeres with or without the use of vitamin supplements.
Vakonaki E. Fragkiadaki P, Tsoukalas D, Alegkakis A, Salatai A, Kouvidi E, Kaloudis K,  Tzatzarakis M, Tsatsakis AM.Eurotox 31 May 2016.

Can dietary Omega 3 fatty acids reduce asthma symptoms in children? Preliminary results of a randomized controlled trial.
Maria Michelle Papamichael, Charis Katsardis, Dimitris Tsoukalas, Bircan Erbas and Catherine Itsiopoulos LaTrobe University, Australia National & Kapodistrian University of Athens, Greece European Institute of Nutritional Medicine, Italy.Pediatric Healthcare & Pediatric Infections. 10th American Pediatrics healthcare & Pediatric Infectious Diseases Congress September 20-22, 2017 | Toronto, Canada.

Telomeres length as ageing biomarker in glyphosate users.
Tsoukalas D, Vakonaki E, Fragkiadaki P, Alegkakis A, Plaitis S, Tsiminikaki K, Vaki G, Fragkiadoulaki E, Tzatzarakis M, Tsatsakis A.BIOTECH Congress, Moscow, 20-22 February, 2017.

A Mediterranean diet enriched with ω3-polyunsaturated fatty acids in the management of paediatric asthma: a randomized control trial.
M M Papamichael1, Ch Katsardis2, D Tsoukalas3, B Erbas1 and C Itsiopoulos1.
1.La Trobe University, Australia
2. National & Kapodistrian University of Athens, Greece,
3. European Institute of Nutritional Medicine, Italy.13th International Congress on Advances in Natural Medicines Nutraceuticals & Neurocognition & 14th International Conference on Clinical Nutrition, July 27-29, 2017 Rome, Italy.

Telomere analysis of metaphase spreads by Q-FISH in individuals of different age groups.
Vakonaki E, Fragkiadaki P, Tsoukalas D, Kouvidi E, Tzatzarakis M, Alegkakis A, Vynias D, Tsatsakis AM.9th Congress of the Turkish Society of Toxicology with the participation of the Hellenic Society of Toxicolog, October 21-24, 2015, Cesme Altin Yunus hotel, Izmir, Turkey.

Telomere analysis of metaphase spreads by Q-FISH in individuals of different age groups.
Elena Vakonaki, Persefoni Fragkiadaki, Dimitrios Tsoukalas, Elisavet Kouvidi, Manolis Tzatzarakis, Athanasios Alegkakis,Dionisios Vynias, Aristidis M. Tsatsakis.Occupational and Environmental Diseases Congress March 2015.

Morbidity analysis of the National health system ambulatories in the region of Zakynthos Greece.
Tsucalas D, Glezos V. 16th National Congress of General Medicine Apr 2004.

Treatment of abdominal trauma in the periphery.
Kosmadakis N, Tsucalas D, Kapsabellis P. 6th Peloponesian Medical Congress Oct. 2004.

Varicose veins – surgical treatment.
Lagodimos S, Milonas I, Tsucalas D. 12th Seminar of the medical association of Corfu. Apr. 2003

Surgical treatment of gastric ulcer.
Kapsabelis P, Palli E, Tsucalas D, 23rd National Congress of Gastroenterology Oct. 2003.

Cost evaluation of pharmaceutical treatments during the year 2000 in the Urban Type National Health Center of Byron.
Tsucalas D, Androulakis G.13rd National Congress of General Medicine Apr. 2001.

Psychiatric disorders follow up in the Urban Type National Health Center of Byron.
Tsucalas D, Papageorgaki P.13rd National Congress of General Medicine Apr. 2001.

Low intraabdominal pressure during laparoscopic cholecystectomy.
Bithoulkas K, Tsucalas D, Kapsabelis P.Laparoscopy 1999; 1 sup:32.

Treatment and follow up of patients with gastro-duodenal ulcer.
Svoronou A, Tsucalas D, Mylonaki D, Romanos A.11th National congress of General Medicine. Apr. 1999 Corfu Greece.

Treatment and follow up of patients with intestinal polyps.
Tsucalas D, Mylonaki D, Romanos A.11th National congress of General Medicine. Apr. 1999 Corfu Greece.

Comparison of different ways of chemoprofilaxis in hernial surgery.
Milonaki D, Tsucalas D, Androulakis G.3rd Symposium on the control of surgical infection Apr. 1999 Florence Italy.

Primary health care contribution in surgical emergency medicine.
Tsucalas D, Svoronou A, Androulakis G.10th national congress of General Medicine Apr 1998.

Treatment of low gastric system hemorrhage.
Katergiannakis B, Tsucalas D, Androulakis G.XXI National congress of Surgery 1998 Athens Greece.

Our 10 year experience on the operation of the short-period hospitalization unit.
Katergiannakis B, Tsucalas D, Androukalis G.XXI National congress of Surgery 1998 Athens Greece.

Addressing of patients under anticoagulant treatment in the short-period hospitalization unit.
Katergiannakis B, Tsucalas D, Androukalis G.9th Cretan congress of Surgery Nov. 1998 Herakleion Greece.

Addressing of patients with diabetes mellitus in the short-period hospitalization unit.
Katergiannakis B, Tsucalas D, Androukalis G.9th Cretan congress of Surgery Nov. 1998 Herakleion Greece.

The correction of inguinal hernia in the elderly with revised Liechtenstein technique.
Kapsabelis P, Tsucalas D.5th National congress of geriatric medicine Athens Greece. Dec 1997.

Acute cholecystitis, which is the timing of the surgical treatment.
Kapsabellis P, Tsucalas D.British Journal of Surgery 1996. 88 sup: 9-10.

Monografia, sindrome di Cushing, MD
Thesis 1991. Universita’ degli Studi di Napoli Federico II.Tsucalas D, Prof. D’Alessandro B.